There are
2,326 mi
from Middletown, OH to Vacaville, CA
That's the driving distance. It would take 1 day 16 hours to go from Middletown, Ohio to Vacaville, California.
The flight distance (direct flight from Middletown, OH to Vacaville, CA) is 2,007.07 mi.
2,326 mi = 3,743.31 kms