There are
350 mi
from Middletown, OH to Sycamore, IL
That's the driving distance. It would take 7 hours 3 mins to go from Middletown, Ohio to Sycamore, Illinois.
The flight distance (direct flight from Middletown, OH to Sycamore, IL) is 282.07 mi.
350 mi = 563.93 kms