There are
1,225 mi
from Middletown, OH to Seguin, TX
That's the driving distance. It would take 21 hours 44 mins to go from Middletown, Ohio to Seguin, Texas.
The flight distance (direct flight from Middletown, OH to Seguin, TX) is 1,031.45 mi.
1,225 mi = 1,971.80 kms