There are
2,378 mi
from Middletown, OH to San Anselmo, CA
That's the driving distance. It would take 1 day 17 hours to go from Middletown, Ohio to San Anselmo, California.
The flight distance (direct flight from Middletown, OH to San Anselmo, CA) is 2,043.91 mi.
2,378 mi = 3,826.32 kms