There are
679 mi
from Middletown, OH to Poughkeepsie, NY
That's the driving distance. It would take 12 hours 51 mins to go from Middletown, Ohio to Poughkeepsie, New York.
The flight distance (direct flight from Middletown, OH to Poughkeepsie, NY) is 569.53 mi.
679 mi = 1,092.77 kms