There are
350 mi
from Middletown, OH to Paducah, KY
That's the driving distance. It would take 6 hours 37 mins to go from Middletown, Ohio to Paducah, Kentucky.
The flight distance (direct flight from Middletown, OH to Paducah, KY) is 283.03 mi.
350 mi = 562.75 kms