There are
953 mi
from Middletown, OH to Opelousas, LA
That's the driving distance. It would take 17 hours 41 mins to go from Middletown, Ohio to Opelousas, Louisiana.
The flight distance (direct flight from Middletown, OH to Opelousas, LA) is 756.99 mi.
953 mi = 1,534.15 kms