There are
1,859 mi
from Middletown, OH to Mesquite, NV
That's the driving distance. It would take 1 day 9 hours to go from Middletown, Ohio to Mesquite, Nevada.
The flight distance (direct flight from Middletown, OH to Mesquite, NV) is 1,615.29 mi.
1,859 mi = 2,992.25 kms