There are
484 mi
from Middletown, OH to Little Chute, WI
That's the driving distance. It would take 9 hours 36 mins to go from Middletown, Ohio to Little Chute, Wisconsin.
The flight distance (direct flight from Middletown, OH to Little Chute, WI) is 385.93 mi.
484 mi = 778.76 kms