There are
367 mi
from Middletown, OH to Kewanee, IL
That's the driving distance. It would take 7 hours 22 mins to go from Middletown, Ohio to Kewanee, Illinois.
The flight distance (direct flight from Middletown, OH to Kewanee, IL) is 314.41 mi.
367 mi = 590.19 kms