There are
640 mi
from Middletown, OH to Escanaba, MI
That's the driving distance. It would take 11 hours 47 mins to go from Middletown, Ohio to Escanaba, Michigan.
The flight distance (direct flight from Middletown, OH to Escanaba, MI) is 451.22 mi.
640 mi = 1,030.48 kms