There are
900 mi
from Mesquite, TX to Zionsville, IN
That's the driving distance. It would take 15 hours 56 mins to go from Mesquite, Texas to Zionsville, Indiana.
The flight distance (direct flight from Mesquite, TX to Zionsville, IN) is 758.80 mi.
900 mi = 1,448.04 kms