There are
478 mi
from Mesquite, TX to Thibodaux, LA
That's the driving distance. It would take 8 hours 38 mins to go from Mesquite, Texas to Thibodaux, Louisiana.
The flight distance (direct flight from Mesquite, TX to Thibodaux, LA) is 397.99 mi.
478 mi = 769.09 kms