There are
1,665 mi
from Mesquite, TX to South Lake Tahoe, CA
That's the driving distance. It would take 1 day 6 hours to go from Mesquite, Texas to South Lake Tahoe, California.
The flight distance (direct flight from Mesquite, TX to South Lake Tahoe, CA) is 1,372.65 mi.
1,665 mi = 2,679.15 kms