There are
853 mi
from Mesquite, TX to Sioux Falls, SD
That's the driving distance. It would take 15 hours 4 mins to go from Mesquite, Texas to Sioux Falls, South Dakota.
The flight distance (direct flight from Mesquite, TX to Sioux Falls, SD) is 745.07 mi.
853 mi = 1,372.72 kms