There are
676 mi
from Mesquite, TX to Shiloh, IL
That's the driving distance. It would take 12 hours 12 mins to go from Mesquite, Texas to Shiloh, Illinois.
The flight distance (direct flight from Mesquite, TX to Shiloh, IL) is 549.06 mi.
676 mi = 1,088.41 kms