There are
881 mi
from Mesquite, TX to Seymour, IN
That's the driving distance. It would take 15 hours 42 mins to go from Mesquite, Texas to Seymour, Indiana.
The flight distance (direct flight from Mesquite, TX to Seymour, IN) is 735.78 mi.
881 mi = 1,417.94 kms