There are
1,362 mi
from Mesquite, TX to Santee, CA
That's the driving distance. It would take 23 hours 16 mins to go from Mesquite, Texas to Santee, California.
The flight distance (direct flight from Mesquite, TX to Santee, CA) is 1,181.45 mi.
1,362 mi = 1.61 kms