There are
1,128 mi
from Mesquite, TX to Sanford, NC
That's the driving distance. It would take 21 hours 12 mins to go from Mesquite, Texas to Sanford, North Carolina.
The flight distance (direct flight from Mesquite, TX to Sanford, NC) is 1,012.39 mi.
1,128 mi = 1.61 kms