There are
1,076 mi
from Mesquite, TX to Sanford, FL
That's the driving distance. It would take 20 hours 7 mins to go from Mesquite, Texas to Sanford, Florida.
The flight distance (direct flight from Mesquite, TX to Sanford, FL) is 948.89 mi.
1,076 mi = 1.61 kms