There are
1,598 mi
from Mesquite, TX to Poughkeepsie, NY
That's the driving distance. It would take 1 day 5 hours to go from Mesquite, Texas to Poughkeepsie, New York.
The flight distance (direct flight from Mesquite, TX to Poughkeepsie, NY) is 1,386.08 mi.
1,598 mi = 1.61 kms