There are
1,716 mi
from Mesquite, TX to Palo Alto, CA
That's the driving distance. It would take 1 day 6 hours to go from Mesquite, Texas to Palo Alto, California.
The flight distance (direct flight from Mesquite, TX to Palo Alto, CA) is 1,474.69 mi.
1,716 mi = 2,762.32 kms