There are
1,413 mi
from Mesquite, TX to Palmdale, CA
That's the driving distance. It would take 1 day to go from Mesquite, Texas to Palmdale, California.
The flight distance (direct flight from Mesquite, TX to Palmdale, CA) is 1,241.18 mi.
1,413 mi = 2,273.80 kms