There are
946 mi
from Mesquite, TX to Orland Park, IL
That's the driving distance. It would take 16 hours 43 mins to go from Mesquite, Texas to Orland Park, Illinois.
The flight distance (direct flight from Mesquite, TX to Orland Park, IL) is 777.99 mi.
946 mi = 1,522.63 kms