There are
697 mi
from Mesquite, TX to Opelika, AL
That's the driving distance. It would take 12 hours 50 mins to go from Mesquite, Texas to Opelika, Alabama.
The flight distance (direct flight from Mesquite, TX to Opelika, AL) is 652.12 mi.
697 mi = 1,121.85 kms