There are
1,380 mi
from Mesquite, TX to Niagara Falls, NY
That's the driving distance. It would take 1 day 1 hour to go from Mesquite, Texas to Niagara Falls, New York.
The flight distance (direct flight from Mesquite, TX to Niagara Falls, NY) is 1,189.77 mi.
1,380 mi = 1.61 kms