There are
352 mi
from Mesquite, TX to Neosho, MO
That's the driving distance. It would take 6 hours 52 mins to go from Mesquite, Texas to Neosho, Missouri.
The flight distance (direct flight from Mesquite, TX to Neosho, MO) is 310.38 mi.
352 mi = 566.60 kms