There are
963 mi
from Mesquite, TX to Middletown, OH
That's the driving distance. It would take 17 hours 18 mins to go from Mesquite, Texas to Middletown, Ohio.
The flight distance (direct flight from Mesquite, TX to Middletown, OH) is 823.93 mi.
963 mi = 1,550.52 kms