There are
868 mi
from Mesquite, TX to Lexington, KY
That's the driving distance. It would take 15 hours 24 mins to go from Mesquite, Texas to Lexington, Kentucky.
The flight distance (direct flight from Mesquite, TX to Lexington, KY) is 771.61 mi.
868 mi = 1,397.49 kms