There are
1,436 mi
from Mesquite, TX to Laguna Niguel, CA
That's the driving distance. It would take 1 day to go from Mesquite, Texas to Laguna Niguel, California.
The flight distance (direct flight from Mesquite, TX to Laguna Niguel, CA) is 1,220.19 mi.
1,436 mi = 1.61 kms