There are
832 mi
from Mesquite, TX to Jeffersonville, IN
That's the driving distance. It would take 14 hours 45 mins to go from Mesquite, Texas to Jeffersonville, Indiana.
The flight distance (direct flight from Mesquite, TX to Jeffersonville, IN) is 719.01 mi.
832 mi = 1,338.44 kms