There are
1,317 mi
from Mesquite, TX to Jamestown, NY
That's the driving distance. It would take 1 day to go from Mesquite, Texas to Jamestown, New York.
The flight distance (direct flight from Mesquite, TX to Jamestown, NY) is 1,146.76 mi.
1,317 mi = 2,119.16 kms