There are
664 mi
from Mesquite, TX to Hopkinsville, KY
That's the driving distance. It would take 12 hours 6 mins to go from Mesquite, Texas to Hopkinsville, Kentucky.
The flight distance (direct flight from Mesquite, TX to Hopkinsville, KY) is 588.91 mi.
664 mi = 1,068.31 kms