There are
903 mi
from Mesquite, TX to Greeneville, TN
That's the driving distance. It would take 16 hours 5 mins to go from Mesquite, Texas to Greeneville, Tennessee.
The flight distance (direct flight from Mesquite, TX to Greeneville, TN) is 817.82 mi.
903 mi = 1,453.91 kms