There are
906 mi
from Mesquite, TX to Greeneville, TN
That's the driving distance. It would take 16 hours 5 mins to go from Mesquite, Texas to Greeneville, Tennessee.
The flight distance (direct flight from Mesquite, TX to Greeneville, TN) is 817.82 mi.
906 mi = 1,457.29 kms