There are
1,445 mi
from Mesquite, TX to Canandaigua, NY
That's the driving distance. It would take 1 day 2 hours to go from Mesquite, Texas to Canandaigua, New York.
The flight distance (direct flight from Mesquite, TX to Canandaigua, NY) is 1,260.27 mi.
1,445 mi = 1.61 kms