There are
659 mi
from Mesquite, TX to Cahokia, IL
That's the driving distance. It would take 11 hours 50 mins to go from Mesquite, Texas to Cahokia, Illinois.
The flight distance (direct flight from Mesquite, TX to Cahokia, IL) is 538.44 mi.
659 mi = 1,060.20 kms