There are
352 mi
from Mesa, AZ to Rancho Cucamonga, CA
That's the driving distance. It would take 6 hours 22 mins to go from Mesa, Arizona to Rancho Cucamonga, California.
The flight distance (direct flight from Mesa, AZ to Rancho Cucamonga, CA) is 334.36 mi.
352 mi = 567.10 kms