There are
2,164 mi
from Medford, OR to Sycamore, IL
That's the driving distance. It would take 1 day 13 hours to go from Medford, Oregon to Sycamore, Illinois.
The flight distance (direct flight from Medford, OR to Sycamore, IL) is 1,739.37 mi.
2,164 mi = 3,481.97 kms