There are
1,825 mi
from Medford, OR to Sioux Falls, SD
That's the driving distance. It would take 1 day 7 hours to go from Medford, Oregon to Sioux Falls, South Dakota.
The flight distance (direct flight from Medford, OR to Sioux Falls, SD) is 1,321.25 mi.
1,825 mi = 2,936.85 kms