There are
2,074 mi
from Medford, OR to Seguin, TX
That's the driving distance. It would take 1 day 12 hours to go from Medford, Oregon to Seguin, Texas.
The flight distance (direct flight from Medford, OR to Seguin, TX) is 1,639.26 mi.
2,074 mi = 3,338.40 kms