There are
2,485 mi
from Medford, OR to Picayune, MS
That's the driving distance. It would take 1 day 21 hours to go from Medford, Oregon to Picayune, Mississippi.
The flight distance (direct flight from Medford, OR to Picayune, MS) is 2,001.19 mi.
2,485 mi = 3.22 kms