There are
2,318 mi
from Medford, OR to Opelousas, LA
That's the driving distance. It would take 1 day 18 hours to go from Medford, Oregon to Opelousas, Louisiana.
The flight distance (direct flight from Medford, OR to Opelousas, LA) is 1,882 mi.
2,318 mi = 3,730.48 kms