There are
1,963 mi
from Medford, OR to Mesquite, TX
That's the driving distance. It would take 1 day 12 hours to go from Medford, Oregon to Mesquite, Texas.
The flight distance (direct flight from Medford, OR to Mesquite, TX) is 1,575.23 mi.
1,963 mi = 3,158.35 kms