There are
2,945 mi
from Medford, OR to Knightdale, NC
That's the driving distance. It would take 2 days 4 hours to go from Medford, Oregon to Knightdale, North Carolina.
The flight distance (direct flight from Medford, OR to Knightdale, NC) is 2,396.52 mi.
2,945 mi = 4,739.26 kms