There are
2,405 mi
from Medford, OR to Jeffersonville, IN
That's the driving distance. It would take 1 day 18 hours to go from Medford, Oregon to Jeffersonville, Indiana.
The flight distance (direct flight from Medford, OR to Jeffersonville, IN) is 1,961.08 mi.
2,405 mi = 3,871.15 kms