There are
1,959 mi
from Medford, OR to Desoto, TX
That's the driving distance. It would take 1 day 12 hours to go from Medford, Oregon to Desoto, Texas.
The flight distance (direct flight from Medford, OR to Desoto, TX) is 1,569.20 mi.
1,959 mi = 3,153.08 kms