There are
2,407 mi
from Medford, OR to Clarksville, IN
That's the driving distance. It would take 1 day 18 hours to go from Medford, Oregon to Clarksville, Indiana.
The flight distance (direct flight from Medford, OR to Clarksville, IN) is 1,959.47 mi.
2,407 mi = 3,873.25 kms