There are
2,223 mi
from Medford, OR to Antioch, IL
That's the driving distance. It would take 1 day 14 hours to go from Medford, Oregon to Antioch, Illinois.
The flight distance (direct flight from Medford, OR to Antioch, IL) is 1,761.94 mi.
2,223 mi = 3,577.48 kms