There are
1,590 mi
from Medford, OR to Amarillo, TX
That's the driving distance. It would take 1 day 5 hours to go from Medford, Oregon to Amarillo, Texas.
The flight distance (direct flight from Medford, OR to Amarillo, TX) is 1,231.06 mi.
1,590 mi = 2,558.42 kms