There are
1,594 mi
from Manchester, NH to Sioux Falls, SD
That's the driving distance. It would take 1 day 5 hours to go from Manchester, New Hampshire to Sioux Falls, South Dakota.
The flight distance (direct flight from Manchester, NH to Sioux Falls, SD) is 1,265.71 mi.
1,594 mi = 2,565.53 kms